Hyunho Lee

This study identifies pegRNA misfolding as a factor limiting CRISPR prime editing efficiency and shows refolding and point mutations can significantly improve it in zebrafish embryos.

This paper introduces BCR-SORT, a deep learning model that predicts B cell subsets from BCR sequences, revealing inter-individual heterogeneity in memory B cell evolution post-COVID-19 vaccination.

GRIP improves cancer patient survival prediction by modeling immune repertoires as hierarchical graphs, outperforming set-based methods and providing interpretable results.

ONE-seq identifies population-specific off-target effects of CRISPR gene editors using global human genome sequence diversity.