A cadherin mutation in Celsr3 linked to Tourette Disorder affects dendritic patterning and excitability of cholinergic interneurons
Lauren A. Poppi, Khue-Tu Ho-Nguyen, Junbing Wu, Matthew J. Matrongolo, Joshua K. Thackray, Cara Nasello, Anna Shi, Matthew R. Ricci, Nicolas L. Carayannopoulos, Nithisha Cheedalla, Julianne McGinnis, Samantha Schaper, Cynthia T. Daut, Jurdiana Hernandez, Gary A. Heiman, , Max A. Tischfield
This study shows a CELSR3 mutation linked to Tourette disorder alters dendritic patterning and excitability of cholinergic interneurons in mice without overt behavioral symptoms.
bioRxiv · Mar 6, 2022 · PreprintNeuroscience