Gary A. Heiman

This study identifies 19 differentially expressed genes in whole-blood transcriptome profiles of Tourette Disorder patients, achieving high classification accuracy using machine learning models.

The paper generates mouse models with human mutations in TD genes, showing sensorimotor and reward learning phenotypes, dopamine changes, and sex-specific effects.

This study shows a CELSR3 mutation linked to Tourette disorder alters dendritic patterning and excitability of cholinergic interneurons in mice without overt behavioral symptoms.

This study identifies two novel genetic loci associated with Tourette Syndrome through a genome-wide meta-analysis and integrates functional data to implicate specific genes.

The paper investigates gene-environment interactions related to tic severity by analyzing SNPs from GWASs of Tourette syndrome and related disorders in interaction with pre- and perinatal adversity.

The paper investigates how polygenic risk scores and environmental factors contribute to tic occurrence in a cohort study, finding additive and mediated effects.

This study identifies gene sets associated with Tourette Syndrome using genome-wide data, highlighting synaptic and immune-related pathways.