Myelin pathology is a key feature of X-linked Dystonia Parkinsonism
Priya Prakash, Kerry C. Limberg, Weimin Zhang, Yu Zhao, Klaudia Flóra Laborc, Anna O'Keeffe, Bryanna C. Vilnaigre, Heather L. Appleby, Michael R. O’Dea, Cara Fernandez‐Cerado, G. Paul Legarda, Michelle Ann C. Sy, Edwin L. Muñoz, Mark Angelo C. Ang, Cid Czarina E. Diesta, , Shane Antony Liddelow
This study introduces a humanized mouse model of XDP with SVA_F insertion in TAF1, revealing myelin loss and oligodendrocyte dysfunction as key pathogenic features.
bioRxiv · Oct 7, 2025 · PreprintNeuroscience