Kerry C. Limberg

The paper shows that IFNγ and proinflammatory cytokines activate astrocytes to express antigen-presenting machinery, supporting CD4+ T cell restimulation in vitro and in vivo.

This study introduces a humanized mouse model of XDP with SVA_F insertion in TAF1, revealing myelin loss and oligodendrocyte dysfunction as key pathogenic features.

The paper genomically rewrote a mouse Taf1 allele with a human XDP patient-derived TAF1 allele, revealing that intronic SVA retrotransposons reduce TAF1 levels and cause neurodegeneration.