Adam C. Mar

This study shows that border-associated macrophages (BAM) are critical in limiting Alzheimer's Disease progression by clearing beta-amyloid, and their loss accelerates disease pathology.

This study introduces a humanized mouse model of XDP with SVA_F insertion in TAF1, revealing myelin loss and oligodendrocyte dysfunction as key pathogenic features.

This paper presents a single-domain antibody-based protein degrader that reduces tau levels and improves motor function in tauopathy models.

This study shows that cysteine restriction in mice causes rapid weight loss by depleting glutathione and coenzyme A, activating stress responses, and increasing lipolysis.

This study shows carbonic anhydrase inhibitors prevent capillary flow issues in a mouse model of early Alzheimer's disease before symptoms appear.

The paper identifies a hypothalamic oxytocin circuit that mediates defeat-induced social avoidance learning in mice.

This study tests FDA-approved carbonic anhydrase inhibitors in a transgenic AD model, finding they reduce amyloid beta pathology and improve cognition by enhancing cerebrovascular health and glial function.

The paper shows that experienced female mice can improve maternal-infant survival by assisting in caregiving and parturition, particularly for mice lacking the oxytocin receptor.

This study shows that inhibiting LXRα phosphorylation in hematopoietic cells reduces inflammation and improves atherosclerosis and obesity by altering macrophage and adipose tissue gene expression.

The paper shows that social interactions between mother mice and virgin mice activate oxytocin neurons, enabling the virgins to acquire maternal behavior through social transmission.