Priya Prakash

This study introduces a humanized mouse model of XDP with SVA_F insertion in TAF1, revealing myelin loss and oligodendrocyte dysfunction as key pathogenic features.

The paper genomically rewrote a mouse Taf1 allele with a human XDP patient-derived TAF1 allele, revealing that intronic SVA retrotransposons reduce TAF1 levels and cause neurodegeneration.

The paper benchmarks PIPseq, a single-cell RNA sequencing method, across different scales and models, showing its ability to detect cell types and differentially expressed genes.

This study develops a fluorescent Aβ analogue to monitor glial cell phagocytosis of amyloid β in real time, showing microglia uptake exceeds astrocytes.