Shane Antony Liddelow

IFNγ and proinflammatory cytokines cooperatively license astrocytes to support antigen-dependent CD4+ T cell restimulation

The paper shows that IFNγ and proinflammatory cytokines activate astrocytes to express antigen-presenting machinery, supporting CD4+ T cell restimulation in vitro and in vivo.

Ancient Somatosensory Circuit Architectures Employ Flexible Molecular Strategies

This study shows that while spinal somatosensory circuit organization is conserved in skates, molecular programs specifying sensory neuron subtypes are distinct from mammals.

Astrocytes mediate a positive feedback loop for oxytocin

The paper shows that astrocytes mediate a positive feedback loop for oxytocin by upregulating its expression through retinoic acid synthesis.

Microglia coordinate activity-dependent protein synthesis in neurons through metabolic coupling

The paper shows microglia support neuronal protein synthesis by coordinating metabolic coupling in response to increased demand from motor tasks.

Myelin pathology is a key feature of X-linked Dystonia Parkinsonism

This study introduces a humanized mouse model of XDP with SVA_F insertion in TAF1, revealing myelin loss and oligodendrocyte dysfunction as key pathogenic features.

Genome writing to dissect consequences of SVA retrotransposon disease X-Linked Dystonia Parkinsonism

The paper genomically rewrote a mouse Taf1 allele with a human XDP patient-derived TAF1 allele, revealing that intronic SVA retrotransposons reduce TAF1 levels and cause neurodegeneration.

Astrocytes connect specific brain regions through plastic gap junctional networks

The paper shows astrocyte gap junction networks selectively connect specific brain regions and reorganize after sensory deprivation in mice.

Immunotherapy-related cognitive impairment after CAR T cell therapy in mice

This study shows that CAR T cell therapy in mice causes cognitive impairment through CNS immune dysregulation, microglial reactivity, and disrupted oligodendroglial homeostasis.

Epigenetic memory astrocytes are likely an artifact of immune cell contamination

This paper challenges the existence of epigenetic memory astrocytes by showing their identification is likely due to immune cell contamination and methodological artifacts.

Defining the molecular identity and morphology of glia limitans superficialis astrocytes in mouse and human

The paper identifies Myocilin as a marker for glia limitans superficialis astrocytes in mouse and human, showing their specialized morphology and evolutionary conservation.

Generation of morphologically distinct astrocyte subtypes from human iPSCs reveals a link between glial shape, function and reactivity

The paper generates morphologically distinct astrocyte subtypes from human iPSCs and links their shape, function, and reactivity.

Temporal and spatial analysis of astrocytes following stroke identifies novel drivers of reactivity

The paper analyzes astrocyte gene expression changes after stroke using spatial transcriptomics and single nucleus RNA-seq to identify novel reactive substates and their functional roles.

Blocking Formation of Neurotoxic Reactive Astrocytes is Beneficial Following Stroke

The paper shows that blocking TIC cytokines reduces neurotoxic astrocyte formation, leading to less brain damage and better recovery after stroke.

Sex Chromosomes and Gonads Shape the Sex-Biased Transcriptomic Landscape in Tlr7-Mediated Demyelination During Aging

The paper identifies sex-biased transcriptomic responses in aged demyelination, showing Tlr7 mediates these differences through interactions with sex chromosomes and gonads.

Determinants of Motor Neuron Functional Subtypes Important for Locomotor Speed

The paper identifies molecular signatures and transcription factors that determine functional subtypes of motor neurons in zebrafish, showing their role in fast MN development.

Single-cell analysis of the nervous system at small and large scales with instant partitions

The paper benchmarks PIPseq, a single-cell RNA sequencing method, across different scales and models, showing its ability to detect cell types and differentially expressed genes.

Silencing neuroinflammatory reactive astrocyte activating factors ameliorates disease outcomes in perinatal white matter injury

This study shows that reducing C3-expressing reactive astrocytes in a mouse model of perinatal white matter injury improves myelination and behavioral outcomes, and identifies these cells as potential therapeutic targets in human WMI.

INPP5D limits plaque formation and glial reactivity in the APP/PS1 mouse model of Alzheimer's disease

The paper shows that INPP5D reduces plaque formation and glial reactivity in Alzheimer's disease mouse models through microglial knockdown and spatial transcriptomics analysis.

Time series scRNAseq analysis in mouse and human informs optimization of rapid astrocyte differentiation protocols.

The paper uses scRNAseq data from mouse and human to identify candidate genes for glial fate specification and optimize astrocyte differentiation protocols.

Monitoring phagocytic uptake of amyloid β into glial cell lysosomes in real time

This study develops a fluorescent Aβ analogue to monitor glial cell phagocytosis of amyloid β in real time, showing microglia uptake exceeds astrocytes.

CD49f is a novel marker to purify functional human iPSC-derived astrocytes

This study identifies CD49f as a marker to isolate functional human iPSC-derived astrocytes, which can be stimulated to exhibit a neurotoxic phenotype relevant to neurodegenerative diseases.

Cell-autonomous regulation of astrocyte activation by the circadian clock protein BMAL1

This study shows BMAL1 regulates astrocyte activation and function through cell-autonomous and non-cell-autonomous mechanisms, impacting neuronal survival and brain health.