Integrated Interactomics Reveals Novel Protein Associations: The FOXA1-PBX1 Complex as a Case Study
Zhi Chen, István Szepesi-Nagy, Qingyue Zhang, Srushti Kittane, Yangzhenyu Gao, Juliana Ortiz-Pacheco, Ethan Lane, Justin Hatcher, Jeffrey Estrada, Manor Askenazi, L Huang, Beatrix M. Ueberheide, Ning Zheng, Eneda Toska, Gergely Róna, Michele Pagano
The paper integrates multiple affinity purification strategies to uncover novel protein interactions, validating the FOXA1-PBX1 complex as a regulatory node in estrogen receptor transcription.
bioRxiv · Jul 17, 2026 · PreprintBiochemistry