Manor Askenazi

The paper integrates multiple affinity purification strategies to uncover novel protein interactions, validating the FOXA1-PBX1 complex as a regulatory node in estrogen receptor transcription.

This study shows D-type cyclins inhibit mismatch repair (MMR) in G1 phase by shielding p21, while their degradation in S phase enables proper MMR function, maintaining genome stability.

The paper compiles and analyzes proteomic data from 38 Alzheimer's disease studies to create a database of protein changes in human brain tissue across disease stages and regions, revealing patterns of protein dysfunction.

The paper identifies proteomic differences in epilepsy brain tissue, highlighting altered protein networks in hippocampus, cortex, and dentate gyrus, with GNB1 as a key decreased protein.

The paper compares proteomic and transcriptomic profiles of hippocampus and cortex in SUDEP and high-risk SUDEP cases, finding no proteomic differences but 55 differentially expressed genes in hippocampus.