Michele Pagano

This study identifies DeSI1 as a cyclin D-CDK4/6 substrate whose phosphorylation regulates membrane and mitochondrial protein supply during proliferation.

Proteogenomic analysis of up to 11 CPTAC cohorts shows ubiquitin-proteasome proteins often diverge from transcripts; TP53-mutant tumors elevate UBR5 protein, while TRIM28 prognosis is lineage-dependent.

The paper integrates multiple affinity purification strategies to uncover novel protein interactions, validating the FOXA1-PBX1 complex as a regulatory node in estrogen receptor transcription.

This study identifies TRIM28 as a critical regulator in acute leukemia, showing its depletion promotes neutrophil differentiation and reduces leukemic potential, with a small-molecule inhibitor developed to target it.

This study identifies GMCL1 as a negative regulator of the mitotic stopwatch pathway, showing it promotes 53BP1 degradation and reduces paclitaxel sensitivity in cancer cells.

This study reveals how two F-box proteins, FBXO22 and FBXL17, recognize distinct structural features of the BACH1 BTB dimer under oxidative stress, leading to its ubiquitination and degradation.

The paper shows cyclin D1-CDK4/6 stabilizes GTSE1, promoting cell proliferation and poor cancer prognosis.

This study identifies PPTC7 as a cofactor for SCFFBXL4-mediated degradation of BNIP3 and NIX, suppressing mitophagy and revealing a feedback mechanism to regulate mitochondrial homeostasis.

This study shows D-type cyclins inhibit mismatch repair (MMR) in G1 phase by shielding p21, while their degradation in S phase enables proper MMR function, maintaining genome stability.

The paper shows mammalian Cryptochromes inhibit CRL4Cop1 complex assembly, similar to their function in plants, by interacting with Det1 to repress GR transcription.