Covalent Targeting of Splicing in T Cells.
K. A. Scott, H. Kojima, N. Ropek, C. D. Warren, T. L. Zhang, S. J. Hogg, C. Webster, X. Zhang, J. Rahman, B. Melillo, B. F. Cravatt, J. Lyu, O. Abdel-Wahab, E. V. Vinogradova
This study develops chemical probes to target splicing factors in T cells, showing state-dependent loss of ITK via SF3B1 and demonstrating covalent ligandability of splicing regulators.
bioRxiv · Dec 18, 2023Immunology