H. Kojima

A novel VCP modulator, KUS121, attenuates atherosclerosis progression by maintaining intracellular ATP and mitigating ER stress in endothelial cells

This study shows that KUS121 reduces atherosclerosis by maintaining ATP levels and reducing ER stress in endothelial cells.

Covalent Targeting of Splicing in T Cells.

This study develops chemical probes to target splicing factors in T cells, showing state-dependent loss of ITK via SF3B1 and demonstrating covalent ligandability of splicing regulators.

Revealing Gene Expression Heterogeneity in a Clonal Population of Tetrahymena thermophila through Single-Cell RNA Sequencing

The paper uses scRNA-seq to analyze gene expression variability in a clonal population of Tetrahymena thermophila, identifying six clusters with distinct functional annotations.

An integrated approach unravels a crucial structural property for the function of the insect steroidogenic Halloween protein Noppera-bo

This paper determines the structure of the insect steroidogenic Halloween protein Noppera-bo and identifies a conserved residue critical for its function.

PITX1 protein interacts with ZCCHC10 to regulate hTERT mRNA transcription

The paper identifies a ZCCHC10-PITX1 complex that suppresses hTERT transcription, contributing to telomerase regulation in melanoma.