Emetine dihydrochloride inhibits Chikungunya virus nsP2 helicase and shows antiviral activity in the cell culture and mouse model of virus infection
Anshula Sharma, Chandru Subramani, K. A. Shouri, Ghanshyam Sharma, Brohmomoy Basu, Abhay Deep Pandey, Archana Rout, Devendra Sharma, Deepti Jain, Sudhanshu Vrati
This paper identifies Emetine dihydrochloride as a potent antiviral against Chikungunya virus, showing reduced viremia and absence of joint swelling in mice.
bioRxiv · Jun 20, 2025 · PreprintMicrobiology