DPP9 directly sequesters the NLRP1 C-terminus to repress inflammasome activation
L. R. Hollingsworth, H. Sharif, A. R. Griswold, P. Fontana, J. Mintseris, K. B. Dagbay, J. A. Paulo, S. P. Gygi, D. A. Bachovchin, H. Wu
This study identifies DPP9 as a repressor of NLRP1 inflammasome activation by sequestering the NLRP1 C-terminus, preventing inflammation during protein turnover.
bioRxiv · Aug 14, 2020Immunology