L. R. Hollingsworth

This study identifies NINJ1's role in membrane rupture through ring formation and amphipathic helices, distinguishing it from NINJ2.

This study reveals how DPP9 regulates CARD8 by forming a ternary complex and shows that DPP9 inhibitors activate CARD8 inflammasomes through two distinct mechanisms.

This study identifies DPP9 as a repressor of NLRP1 inflammasome activation by sequestering the NLRP1 C-terminus, preventing inflammation during protein turnover.

This study reports cryo-EM structures of NLRP1-CT and CARD8-CT inflammasome assemblies, revealing unique filament formation mechanisms and ASC recruitment specificity.

This study uses molecular dynamics simulations to investigate how lipid, water, and ion interactions affect the dynamics of HIV-1 Env gp41 transmembrane domain.