Author

P. Fontana

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biochemistry· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:comparative / phylogenetic analysis· 1 Assay:cryo-EM· 1

Frequent Co-Authors

H. Wu· 3 shared A. R. Griswold· 2 shared D. A. Bachovchin· 2 shared H. Sharif· 2 shared L. David· 2 shared L. R. Hollingsworth· 2 shared A. Banerjee· 1 shared A. Crisanti· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersImmunology

H. Wu

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

ROS-dependent palmitoylation is an obligate licensing modification for GSDMD pore formation

G. Du, L. B. Healy, L. David, C. Walker, P. Fontana, Y. Dong, P. Devant, R. Puthenveetil, S. B. Ficarro, A. Banerjee, J. C. Kagan, J. Lieberman, H. Wu

This study identifies palmitoylation as a required modification for GSDMD pore formation, showing that ROS induces this modification and is essential for membrane translocation and cell death.

bioRxiv · Mar 7, 2023Immunology

Rapid longitudinal SARS-CoV-2 intra-host emergence of novel haplotypes regardless of immune deficiencies

L. Manuto, M. Grazioli, A. Spitaleri, P. Fontana, L. Bianco, L. Bertolotti, M. Bado, G. Mazzotti, F. Bianca, F. Onelia, G. Lorenzin, F. Simeoni, D. Lazarevic, E. Franchin, C. Del Vecchio, , S. Toppo

The paper analyzes SARS-CoV-2 genomic data from a quarantined Italian town, showing rapid intra-host emergence of novel viral haplotypes within two weeks, regardless of immune status or symptoms.

bioRxiv · Dec 22, 2021 · PreprintEvolutionary Biology

DPP9 directly sequesters the NLRP1 C-terminus to repress inflammasome activation

L. R. Hollingsworth, H. Sharif, A. R. Griswold, P. Fontana, J. Mintseris, K. B. Dagbay, J. A. Paulo, S. P. Gygi, D. A. Bachovchin, H. Wu

This study identifies DPP9 as a repressor of NLRP1 inflammasome activation by sequestering the NLRP1 C-terminus, preventing inflammation during protein turnover.

bioRxiv · Aug 14, 2020Immunology

Novel mode of filament formation in UPA-promoted CARD8 and NLRP1 Inflammasomes

L. R. Hollingsworth, L. David, Y. Li, A. R. Griswold, H. Sharif, P. Fontana, T.-M. Fu, J. Ruan, D. A. Bachovchin, H. Wu

This study reports cryo-EM structures of NLRP1-CT and CARD8-CT inflammasome assemblies, revealing unique filament formation mechanisms and ASC recruitment specificity.

bioRxiv · Jun 27, 2020Immunology

A new perspective on the evolution of the interaction between the Vg/VGLL1-3 proteins and the TEAD transcription factors

Y. Mesrouze, G. Aguilar, F. Bokhovchuk, T. Martin, C. Martin, F. Villard, M. Meyerhofer, C. Zimmermann, P. Fontana, R. Wille, T. Vorherr, D. Erdmann, P. Furet, C. Scheufler, T. Schmelzle, , P. Chene

The paper investigates the structural and functional evolution of Vg/VGLL1-3 proteins' interaction with TEAD transcription factors, revealing an additional {Omega}-loop in some variants.

bioRxiv · May 21, 2020Biochemistry