Aortic valve disease augments vesicular microRNA-145-5p to regulate the calcification of valvular interstitial cells via cellular crosstalk
P. R. Goody, D. Christmann, D. Goody, D. Nehl, K. Backer, K. Wilhelm-Juengling, S. Uchida, J. B. Moore, S. Zimmer, F. Bakhtiary, A. Pfeifer, E. Latz, G. Nickenig, F. Jansen, M. R. Hosen
This study identifies miR-145-5p as a key regulator of aortic valve calcification through EV-mediated crosstalk, showing it suppresses ZEB2 to enhance ALPL expression and promote calcification in valvular interstitial cells.
bioRxiv · Nov 29, 2022 · PreprintCell Biology