Author

J. B. Moore

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

J. L. Thorne· 2 shared P. Lianto· 2 shared T. A. Hughes· 2 shared A. Pfeifer· 1 shared A. Rose· 1 shared A. Websdale· 1 shared B. Kim· 1 shared B. Williams· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersCancer Biology

J. L. Thorne

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

PI 3-kinase isoform p110α mediated FOXO1 inactivation protects against aortic aneurysm formation

M. Vantler, M. Schorscher, E. M. Berghausen, M. Zierden, J. Spitzer, J. B. Moore, D. Wong, Z. Li, M. Wissmueller, L. Gnatzy-Feik, D. Unnersjoe-Jess, L.-M. A. Zimmermann, M. Grandoch, D. Mehrkens, M. Adam, , S. Rosenkranz

This study shows that p110α-mediated FOXO1 inactivation in smooth muscle cells prevents aortic aneurysm formation by maintaining vascular homeostasis and promoting reparative SMC phenotypes.

bioRxiv · Dec 1, 2022 · PreprintCell Biology

Aortic valve disease augments vesicular microRNA-145-5p to regulate the calcification of valvular interstitial cells via cellular crosstalk

P. R. Goody, D. Christmann, D. Goody, D. Nehl, K. Backer, K. Wilhelm-Juengling, S. Uchida, J. B. Moore, S. Zimmer, F. Bakhtiary, A. Pfeifer, E. Latz, G. Nickenig, F. Jansen, M. R. Hosen

This study identifies miR-145-5p as a key regulator of aortic valve calcification through EV-mediated crosstalk, showing it suppresses ZEB2 to enhance ALPL expression and promote calcification in valvular interstitial cells.

bioRxiv · Nov 29, 2022 · PreprintCell Biology

Comprehensive profiling of liver x receptor splicing in triple negative breast cancer reveals existence of novel splice variants that are prognostic for survival

P. Lianto, J. B. Moore, T. A. Hughes, J. L. Thorne

The paper identifies novel LXR splice variants in triple negative breast cancer and shows their prognostic significance for patient survival.

bioRxiv · Jun 9, 2021 · PreprintCancer Biology

Liver x receptor alpha drives chemoresistance in response to side-chain hydroxycholesterols in triple negative breast cancer

S. A. Hutchinson, A. Websdale, P. Lianto, G. Cioccoloni, H. Roberg-Larsen, B. Kim, A. Rose, C. Soteriou, L. M. Wastall, B. Williams, M. Henn, J. J. Chen, L. Ma, J. B. Moore, E. R. Nelson, , J. L. Thorne

This study identifies LXRalpha as a driver of chemoresistance in TNBC through its regulation of P-glycoprotein, linking cholesterol metabolism to chemotherapy failure.

bioRxiv · Aug 4, 2020Cancer Biology