SIDT2 RNA transporter promotes lung and gastrointestinal tumor development
T. Nguyen, K. Bieging-Rolett, T. Putoczki, I. Wicks, L. Attardi, K. Pang
The paper shows that SIDT2 promotes tumor development in lung and gastrointestinal cancers by facilitating RNautophagy, as evidenced by reduced tumor formation in Sidt2-/- mice with oncogenic KrasG12D or Apcmin/+ mutations.
bioRxiv · Aug 9, 2019Cancer Biology