C9orf72 arginine-rich dipeptide repeat proteins disrupt importin β-mediated nuclear import
L. R. Hayes, L. Duan, K. Bowen, P. Kalab, J. D. Rothstein
This study shows that C9orf72-derived arginine-rich dipeptide repeat proteins disrupt importin β-mediated nuclear import in neurons and HeLa cells, without causing NCT protein sequestration or FG-rich pore complex blockade.
bioRxiv · Sep 30, 2019Cell Biology