L. R. Hayes

RNA-mediated ribonucleoprotein assembly controls TDP-43 nuclear retention

This study shows that RNA-mediated TDP-43 self-assembly forms macromolecular complexes that retain TDP-43 in the nucleus, preventing cytoplasmic aggregation and highlighting potential therapeutic targets.

Multivalent GU-rich oligonucleotides sequester TDP-43 in the nucleus by inducing high molecular weight RNP complexes

This study shows that multivalent GU-rich oligonucleotides sequester TDP-43 in the nucleus, forming high molecular weight RNPs, but pure GU-repeats impair TDP-43 function.

Nuclear RNA binding regulates TDP-43 nuclear localization and passive nuclear export

This study shows that TDP-43 nuclear localization depends on RNA binding to GU-rich intronic pre-mRNAs and is regulated by transcription and pre-mRNA processing.

C9orf72 arginine-rich dipeptide repeat proteins disrupt importin β-mediated nuclear import

This study shows that C9orf72-derived arginine-rich dipeptide repeat proteins disrupt importin β-mediated nuclear import in neurons and HeLa cells, without causing NCT protein sequestration or FG-rich pore complex blockade.