Biosynthetic engineering of the antifungal, anti-MRSA auroramycin
W. L. Yeo, E. Heng, L. L. Tan, Y. W. Lim, K. C. Ching, D.-J. Tsai, Y. W. Jhang, T.-L. Lauderdale, K.-S. Shia, H. Zhao, E. L. Ang, M. M. Zhang, Y. H. Lim, F. T. Wong
The paper engineers the auroramycin biosynthetic pathway in Streptomyces roseoporous to identify key structural features responsible for its antimicrobial activity.
bioRxiv · Nov 4, 2019Bioengineering