Author

L. L. Tan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Bioengineering· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:bacteria (other)· 3 Research Focus:clustering· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

C. J. Jackson· 2 shared E. Heng· 2 shared F. T. Wong· 2 shared Y. H. Lim· 2 shared A. Delaney· 1 shared A. M. Buckle· 1 shared A. M. Damry· 1 shared A. Villar-Briones· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersBiochemistry

C. J. Jackson

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Application of Cas12j for Streptomyces editing and cluster activation

L. L. Tan, E. Heng, N. Zulkarnain, C. Y. Leong, V. Ng, L. K. Yang, D. C. S. Seow, G. Peh, Y. H. Lim, K. Lokanand, Y. Kanagasundaram, S. B. Ng, F. T. Wong

This study introduces Cas12j for Streptomyces editing, showing improved efficiency over Cas12a and FnCpf1.

bioRxiv · Oct 28, 2021 · PreprintMicrobiology

Substrate dynamics contribute to enzymatic specificity in human and bacterial methionine adenosyltransferases

M. H. GADE, L. L. Tan, A. M. Damry, M. Sandhu, J. S. Brock, A. Delaney, A. Villar-Briones, C. J. Jackson, P. Laurino

This study investigates how substrate conformational dynamics influence enzymatic specificity in human and bacterial methionine adenosyltransferases, revealing differences in catalytic promiscuity and identifying a new metabolite in cancer cells.

bioRxiv · Feb 18, 2021Biochemistry

Mutational and biophysical robustness in a pre-stabilized monobody

P. G. Chandler, L. L. Tan, B. T. Porebski, J. S. Green, B. T. Riley, S. S. Broendum, D. E. Hoke, R. J. Falconer, T. P. Munro, M. Buckle, C. J. Jackson, A. M. Buckle

This paper grafts binding loops from an Adnectin onto a pre-stabilized FN3Con scaffold to create a stable monobody that binds VEGFR2 with high affinity and long-term stability.

bioRxiv · Dec 14, 2020 · PreprintBiochemistry

Biosynthetic engineering of the antifungal, anti-MRSA auroramycin

W. L. Yeo, E. Heng, L. L. Tan, Y. W. Lim, K. C. Ching, D.-J. Tsai, Y. W. Jhang, T.-L. Lauderdale, K.-S. Shia, H. Zhao, E. L. Ang, M. M. Zhang, Y. H. Lim, F. T. Wong

The paper engineers the auroramycin biosynthetic pathway in Streptomyces roseoporous to identify key structural features responsible for its antimicrobial activity.

bioRxiv · Nov 4, 2019Bioengineering