Author

Y. H. Lim

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:bacteria (other)· 3 Research Focus:drug response / drug discovery· 2 Research Focus:clustering· 1 Research Focus:gene regulatory network inference· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Research Focus:variant calling· 1

Frequent Co-Authors

F. T. Wong· 3 shared E. Heng· 2 shared L. L. Tan· 2 shared A. Chandramohan· 1 shared A. Peier· 1 shared A. W. Partridge· 1 shared B. Henry· 1 shared B. Sherborne· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersMicrobiology

F. T. Wong

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Expression and engineering of unexplored PET degrading enzymes from Microbispora, Nonomuraea, Micromonospora genus

E. Tiong, Y. S. Koo, J. Bi, L. Koduru, W. Koh, Y. H. Lim, F. T. Wong

This paper identifies and characterizes novel PET-degrading enzymes from Microbispora, Nonomuraea, and Micromonospora genera, and enhances their activity through engineering.

bioRxiv · Apr 17, 2023 · PreprintMicrobiology

Design-Rules for Stapled Alpha-Helical Peptides with On-Target In Vivo Activity: Application toMdm2/X dual antagonists

A. Chandramohan, H. Josien, T. Yuen, R. Duggal, D. Spiegelberg, L. Yan, Y. C. A. Juang, L. Ge, P. Aronica, H. Y. K. Kaan, Y. H. Lim, A. Peier, B. Sherborne, J. Hochman, S. Lin, , A. W. Partridge

The paper develops design rules for stapled alpha-helical peptides to improve in vivo activity and reduce off-target effects, demonstrating significant improvements in potency and safety.

bioRxiv · Feb 25, 2023 · PreprintBiochemistry

Application of Cas12j for Streptomyces editing and cluster activation

L. L. Tan, E. Heng, N. Zulkarnain, C. Y. Leong, V. Ng, L. K. Yang, D. C. S. Seow, G. Peh, Y. H. Lim, K. Lokanand, Y. Kanagasundaram, S. B. Ng, F. T. Wong

This study introduces Cas12j for Streptomyces editing, showing improved efficiency over Cas12a and FnCpf1.

bioRxiv · Oct 28, 2021 · PreprintMicrobiology

Biosynthetic engineering of the antifungal, anti-MRSA auroramycin

W. L. Yeo, E. Heng, L. L. Tan, Y. W. Lim, K. C. Ching, D.-J. Tsai, Y. W. Jhang, T.-L. Lauderdale, K.-S. Shia, H. Zhao, E. L. Ang, M. M. Zhang, Y. H. Lim, F. T. Wong

The paper engineers the auroramycin biosynthetic pathway in Streptomyces roseoporous to identify key structural features responsible for its antimicrobial activity.

bioRxiv · Nov 4, 2019Bioengineering