Cohesin distribution alone predicts chromatin organization in yeast via conserved-current loop extrusion.
T. Yuan, H. Yan, K. C. Li, I. V. Surovtsev, M. C. King, S. G. J. Mochrie
The paper introduces the CCLE model to predict chromatin organization in yeast using cohesin ChIP-seq data, showing it accurately predicts TADs without relying on CTCF.
bioRxiv · Oct 5, 2023Biophysics