C. Cao

Non-invasive tracking of hippocampal theta oscillations

This paper shows that hippocampal theta oscillations can be detected and tracked non-invasively using MEG, validated across rodent and human datasets.

TurboID-mediated surface protein biotinylation to inhibit the growth of Staphylococcus aureus

This study uses TurboID-mediated biotinylation of surface proteins to inhibit the growth and virulence of multiple S. aureus strains.

Multiomics unveils extracellular vesicle-driven mechanisms of endothelial communication in human carotid atherosclerosis

This study identifies EV-driven endothelial communication in human carotid atherosclerosis, showing increased angiogenic activity in symptomatic plaques.

Exploring new nanopore sensors from the aerolysin family

The paper explores new nanopore sensors from the aerolysin family by analyzing structure and sensing capabilities of three family members, finding ETX can translocate ssDNA with higher sensitivity than aerolysin.

Single-molecule evidence of Entropic Pulling by Hsp70 chaperones

This study uses single-molecule nanopore experiments to demonstrate Hsp70 chaperones exert forces equivalent to 46 pN to extract trapped polypeptides, supporting the Entropic Pulling mechanism.

Dissecting the membrane association mechanism of aerolysin pore at femtomolar concentrations using water as a probe

This study uses AR-SHS and current measurements to analyze aerolysin's membrane association and pore formation at femtomolar concentrations, revealing binding affinities and structural changes during the process.

Deep learning-assisted single-molecule detection of protein post-translational modifications with a biological nanopore

This study uses a biological nanopore and deep learning to detect and distinguish single and multiple PTMs on -synuclein peptides at picomolar concentrations.

A humoral stress response protects Drosophila tissues from antimicrobial peptides

This study identifies Turandot stress proteins that protect Drosophila tissues from antimicrobial peptide-induced damage by binding phosphatidylserine and inhibiting AMP pore formation.

Targeting CD301+ macrophage inhibits endometrial fibrosis and improves pregnancy outcome

This study identifies CD301+ macrophages as drivers of endometrial fibrosis and infertility, showing their inhibition improves pregnancy outcomes in mice.

Longitudinal analysis of memory T follicular helper cells and antibody response following CoronaVac vaccination

This study tracks memory T follicular helper cells and antibody response after three doses of CoronaVac vaccine over 300 days, showing increased neutralizing antibodies and cTFH cells, with correlation between cTFH and antibody titers.

Ebola Virus Sequesters IRF3 in Viral Inclusion Bodies to Evade Host Antiviral Immunity

This study shows Ebola virus uses viral inclusion bodies to sequester IRF3, blocking type I interferon production and evading antiviral immunity.

Host and transmission route of Enterocytozoon hepatopenaei (EHP) from dragonfly to shrimp

This study identifies dragonflies as natural hosts of EHP and confirms horizontal transmission between dragonflies and shrimp.

Spatial transcriptomics reveals distinct and conserved tumor core and edge architectures that predict survival and targeted therapy response

This study uses spatial transcriptomics to analyze tumor core and edge regions in OSCC, revealing distinct transcriptional profiles and their clinical implications across multiple cancers.

Computational Design of Two New Vitamin K Epoxide Reductase Inhibitors

This study designs two new VKOR inhibitors using computational methods, predicting improved ADMET and binding properties over existing drugs.

Single cell Transcriptome and T cell Repertoire Mapping of the Mechanistic Signatures and T cell Trajectories Contributing to Vascular and Dermal Manifestations of Behcet Disease

This study maps single-cell transcriptomes and T cell repertoires in Behcet's disease to identify immune mechanisms and T cell trajectories in vascular and dermal manifestations.

Dynamic control of metabolic zonation and liver repair by endothelial cell Wnt2 and Wnt9b revealed by single cell spatial transcriptomics using Molecular Cartography

This study identifies endothelial cell Wnt2 and Wnt9b as key regulators of liver zonation and repair, showing their therapeutic potential in acute liver failure using single-cell spatial transcriptomics.

Identification of diverse viruses associated with grasshoppers unveils phylogenetic congruence between hosts and viruses

This study identifies 322 viruses in 34 grasshopper species, including 202 novel species, and finds phylogenetic congruence between grasshoppers and certain viral families.

Epigenetic MRI: Noninvasive Imaging of DNA Methylation in the Brain

This paper introduces eMRI, a noninvasive method to image DNA methylation in the brain, revealing regional differences in global DNA methylation in pigs.

Glioblastoma remodeling of neural circuits in the human brain decreases survival

This study shows glioblastomas alter neural circuits in the human brain, reducing survival and impairing cognition through synaptogenic interactions.

Potentiation of Long-Acting β2-Agonist and Glucocorticoid Responses in Human Airway Epithelial Cells by Modulation of Intracellular cAMP

This study shows that inhibiting PDE4 or ABCC4 enhances the anti-inflammatory effects of LABA/GCS in human airway epithelial cells exposed to viral stimuli.

Analysis of the Functional Differentiation Sites in Vertebrate Neuronal Nicotinic Acetylcholine Receptor Subunits

This study identifies function-specific sites in vertebrate neuronal nAChR subunits through evolutionary analysis, revealing unique selection pressures and potential positive selection events.

Histologically resolved spatial multi-omics of human oral squamous cell carcinoma

This paper introduces a technique combining label-free histology with spatially resolved multi-omics to map gene expression and copy number alterations in human oral squamous cell carcinoma.

The physiological adaptation for the "fore-mid" four-legged walking behavior of the pygmy mole cricket Xya sichuanensis

This study identifies a unique 'fore-mid' four-legged walking pattern in Xya sichuanensis, highlighting physiological and behavioral adaptations for survival in its environment.

Structural characterization of the N-terminal domain of the Dictyostelium discoideum mitochondrial calcium uniporter

This study reports the crystal structure of the N-terminal domain of DdMCU and shows its oligomeric state and calcium-dependent dissociation.

DNA-mediated assembly of multi-specific antibodies for T cell engaging and tumor killing

This paper describes a method to assemble multi-specific antibodies using DNA-mediated assembly, showing efficacy in tumor cell cytotoxicity and xenograft suppression.

The microstructure investigation of plant architecture with X-ray microscopy

The paper uses X-ray microscopy to investigate plant microstructure, showing its effectiveness in analyzing plant tissues across species.

IL-10-producing B cells are enriched in murine pericardial adipose tissues and ameliorate the outcome of acute myocardial infarction

This study identifies IL-10-producing B cells in murine pericardial adipose tissues that promote cardiac recovery after acute myocardial infarction by resolving inflammation and reducing myocardial injury.

Root Colonization and Growth Promotion of Soybean, Wheat and Chinese Cabbage by Bacillus cereus YL6

This study shows that Bacillus cereus YL6 promotes growth of soybean, wheat, and Chinese cabbage by solubilizing phosphorus and producing plant hormones, while also colonizing plant roots.

Complex Coding And Regulatory Polymorphisms In A Restriction Factor Determine The Susceptibility Of Drosophila To Viral Infection

This study identifies complex genetic variation in the pastrel gene that influences Drosophila susceptibility to DCV virus, showing how coding and regulatory polymorphisms contribute to resistance.