M. C. King

A quantitative ultrastructural timeline of nuclear autophagy reveals a role for dynamin-like protein 1 at the nuclear envelope

This study quantifies the timeline of nuclear autophagy in yeast, revealing a role for Dnm1 in nuclear envelope remodeling during cargo removal.

Cohesin distribution alone predicts chromatin organization in yeast via conserved-current loop extrusion.

The paper introduces the CCLE model to predict chromatin organization in yeast using cohesin ChIP-seq data, showing it accurately predicts TADs without relying on CTCF.

An ESCRT grommet cooperates with a diffusion barrier to maintain nuclear integrity

The paper investigates ESCRT-III proteins' roles in maintaining nuclear envelope integrity during mitosis and interphase, revealing distinct functions of CHMP7/Cmp7 and a diffusion barrier.

On a mathematical connection between single-elimination sports tournaments and evolutionary trees

The paper connects the enumeration of game sequences in single-elimination sports tournaments to labeled histories in phylogenetics, providing a recursive formula for sequences with simultaneous branching events.

Atg39 selectively captures inner nuclear membrane into lumenal vesicles for delivery to the autophagosome

This study identifies Atg39 as a cargo adaptor that targets inner nuclear membrane components for autophagy by forming lumenal vesicles in the nuclear envelope.

The condensation of HP1-????/Swi6 imparts nuclear stiffness

This study shows that Swi6 condensation provides mechanical stiffness to the nucleus, demonstrating a mechanical function of biomolecular condensates.

Heh2/Man1 may be an evolutionarily conserved sensor of NPC assembly state

The paper shows Heh2/Man1 interacts with NPC components in yeast and suggests it senses NPC assembly state for quality control and segregation.

Homology-directed repair involves multiple strand invasion cycles in fission yeast

This study uses live-cell microscopy to show that homology-directed repair in fission yeast involves multiple strand invasion cycles, with Rqh1 promoting noncrossover repair through repeated co-localization events.

The LINC complex transmits integrin-dependent tension to the nuclear lamina and represses epidermal differentiation

This study shows that the LINC complex transmits integrin-generated tension to the nuclear lamina, repressing epidermal differentiation in stem cells.

Loops and the activity of loop extrusion factors constrain chromatin dynamics

This study investigates how loop extrusion factors and chromatin structure influence chromatin dynamics using microscopy, genetics, and simulations in fission yeast.

Ablation of SUN2-containing LINC complexes drives cardiac hypertrophy without interstitial fibrosis

This study shows that SUN2-null mice develop cardiac hypertrophy without fibrosis, linking LINC complex function to TGFβ signaling and MAN1 regulation.