T. Yuan

Protein-structure-sensitive mid-infrared optoacoustic microscopy enables label-free assessment of drug therapy in myeloma cells

This paper introduces a mid-infrared optoacoustic microscopy technique to label-free monitor drug therapy effects on myeloma cells by detecting intermolecular β-sheet formation.

Cohesin distribution alone predicts chromatin organization in yeast via conserved-current loop extrusion.

The paper introduces the CCLE model to predict chromatin organization in yeast using cohesin ChIP-seq data, showing it accurately predicts TADs without relying on CTCF.

Inhibition of mammalian mtDNA transcription paradoxically activates liver fatty acid oxidation to reverse diet-induced hepatosteatosis and obesity

The paper shows that inhibiting mitochondrial DNA transcription in mice increases fatty acid oxidation, reducing obesity and liver fat while decreasing oxidative phosphorylation capacity.

Exposure to titanium dioxide nanoparticles accelerates abnormal fat deposition through the mediation of the ROS via the AGE-RAGE signaling pathway in mice

This study shows that titanium dioxide nanoparticles induce fat deposition in mice by increasing ROS and activating the AGE-RAGE pathway, with NAC as a potential therapeutic.

Phase-shifting mid-infrared optothermal microscopy for wide-field hyperspectral imaging of living cells

This paper introduces PSOM, a technique for fast live-cell hyperspectral imaging with large FOVs and high confluency, achieving reduced noise and lower photodamage.

Linking fluid-axons interactions to the macroscopic fluid transport properties of the brain

This paper establishes the link between microscale fluid-axon interactions and macroscopic brain transport properties using simulations, introducing an anisotropic pressure-dependent permeability tensor.

Structure of human NaV1.6 channel reveals Na+ selectivity and pore blockade by 4,9-anhydro-tetrodotoxin

The paper presents cryo-EM structures of human NaV1.6 channels with and without 4,9-anhydro-tetrodotoxin, revealing Na+ selectivity and inhibition mechanisms.

Porosity-permeability tensor relationship of closely and randomly packed fibrous biomaterials and biological tissues: Application to the brain white matter

This paper derives an anisotropic porosity-permeability tensor relationship for brain white matter and proposes a model to improve transport property design in fibrous biomaterials.

Abortion occurs during double fertilisation and ovule development in Paeonia ludlowii

This study investigates ovule abortion in Paeonia ludlowii, identifying types, developmental stages, and morphological differences between aborted and fertile ovules.

SARS-CoV-2 Neutralizing Antibody Responses Are More Robust in Patients with Severe Disease

This study finds that patients with severe SARS-CoV-2 disease have higher antibody titers against viral proteins and neutralization capabilities compared to less severe cases.

Loops and the activity of loop extrusion factors constrain chromatin dynamics

This study investigates how loop extrusion factors and chromatin structure influence chromatin dynamics using microscopy, genetics, and simulations in fission yeast.

S100A4 inhibits cell proliferation by interfering with the RAGE V domain-S100A1

This study investigates the interaction between S100A4 and S100A1, revealing that S100A4 inhibits cell proliferation by blocking the RAGE V domain-S100A1 interaction.