K. C. Mok

Soil microbial community response to corrinoids is shaped by a natural reservoir of vitamin B12.

The paper investigates how corrinoid structure affects soil microbial community composition and stability through experimental and genomic analysis.

Laboratory evolution of E. coli with a natural vitamin B12 analog reveals roles for cobamide uptake and adenosylation in methionine synthase-dependent growth

This study evolves E. coli with a less-effective cobamide to identify genetic adaptations that improve growth, finding increased BtuB expression and BtuR overexpression enhance cobamide-dependent growth.

Phylogenetic distribution and experimental characterization of corrinoid production and dependence in soil bacterial isolates

The paper investigates corrinoid production and dependence in soil bacteria to understand metabolic interactions, finding metabolic compatibility and conserved traits across genera.

Cobalamin riboswitches are broadly sensitive to corrinoid cofactors to enable an efficient gene regulatory strategy

The paper investigates cobalamin riboswitches in Bacillus subtilis and finds they respond to multiple corrinoid cofactors, using structural conformation differences for regulation.

Identification of a novel cobamide remodeling enzyme in the beneficial human gut bacterium Akkermansia muciniphila

This paper identifies a novel cobamide remodeling enzyme, CbiR, in Akkermansia muciniphila that enables the bacterium to use diverse cobamides by modifying their structure.

Cofactor selectivity in methylmalonyl-CoA mutase, a model cobamide-dependent enzyme

This study investigates how structural variations in cobamides affect the binding selectivity of methylmalonyl-CoA mutase, showing that in vitro binding correlates with in vivo cobamide dependence.

Uneven distribution of cobamide biosynthesis and dependence in bacteria predicted by comparative genomics

The paper uses comparative genomics to analyze cobamide biosynthesis and dependence in bacteria, finding that most bacteria use cobamides but few synthesize them de novo.