Molecular mechanisms underlying attenuation of live attenuated Japanese encephalitis virus vaccine SA14-14-2
P. Hoovina Venkatesh, S. Kumar, N. Kumar, K. Chaitanya, L. Turtle, V. Satchidanandam
This paper identifies molecular mechanisms of attenuation in the SA14-14-2 Japanese encephalitis vaccine strain, showing loss of NS1 and envelope protein folding defects lead to enhanced immune responses.
bioRxiv · Jan 14, 2021 · PreprintCell Biology