Poor Quality Vβ Recombination Signal Sequences Enforce TCRβ Allelic Exclusion by Limiting the Frequency of Vβ Recombination
G. S. Wu, K. S. Yang-Iott, M. A. Reed, K. E. Hayer, K. D. Lee, C. H. Bassing
The paper shows that poor quality Vβ RSSs limit Vβ recombination, enforcing allelic exclusion by reducing functional rearrangements on both alleles before feedback inhibition.
bioRxiv · Jan 20, 2020Immunology