SARS-CoV-2 Envelope (E) Protein Interacts with PDZ-Domain-2 of Host Tight Junction Protein ZO1
A. Shepley-McTaggart, C. A. Sagum, I. Oliva, E. Rybakovsky, K. DiGuilio, J. Liang, M. T. Bedford, J. Cassel, M. Sudol, J. M. Mullin, R. N. Harty
This study identifies a specific interaction between SARS-CoV-2 E protein and PDZ-domain-2 of ZO1, suggesting a role in epithelial barrier disruption and disease severity.
bioRxiv · Dec 22, 2020Microbiology