Author

M. T. Bedford

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J. Liang· 2 shared M. Sudol· 2 shared R. N. Harty· 2 shared A. Khodadadi-Jamayran· 1 shared A. Shepley-McTaggart· 1 shared A. Tsirigos· 1 shared B. Freedman· 1 shared B. Peng· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersMicrobiology

J. Liang

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Genome-wide analysis of dendritic cell differentiation

I. Tiniakou, P.-F. Hsu, L. S. Lopez-Zepeda, C. M. Lau, C. Soni, E. Esteva, N. Adams, F. Liu, A. Khodadadi-Jamayran, T. Rodrick, D. Jones, A. Tsirigos, U. Ohler, M. T. Bedford, S. D. Nimer, B. Reizis

This study uses a genome-wide CRISPR/Cas9 screen to identify regulators of dendritic cell differentiation in a Flt3L-dependent murine progenitor cell line.

bioRxiv · May 11, 2022 · PreprintImmunology

Molecular basis for SPINDOC-Spindlin1 engagement and its role in transcriptional inhibition

F. Zhao, F. Yang, F. Feng, B. Peng, M. T. Bedford, H. Li

This paper identifies the molecular mechanism by which SPIN*DOC inhibits Spindlin1's transcriptional coactivator activity through multivalent binding and competitive inhibition.

bioRxiv · Mar 7, 2021 · PreprintBiophysics

Angiomotin Counteracts the Negative Regulatory Effect of Host WWOX on Viral PPxY-Mediated Egress

J. Liang, G. Ruthel, C. Sagum, M. T. Bedford, S. Sidhu, M. Sudol, C. K. Jaladanki, H. Fan, B. Freedman, R. N. Harty

This study identifies WWOX as a host protein that interacts with viral PPxY motifs to inhibit virus egress, revealing a competitive interplay with angiomotin.

bioRxiv · Jan 26, 2021Microbiology

SARS-CoV-2 Envelope (E) Protein Interacts with PDZ-Domain-2 of Host Tight Junction Protein ZO1

A. Shepley-McTaggart, C. A. Sagum, I. Oliva, E. Rybakovsky, K. DiGuilio, J. Liang, M. T. Bedford, J. Cassel, M. Sudol, J. M. Mullin, R. N. Harty

This study identifies a specific interaction between SARS-CoV-2 E protein and PDZ-domain-2 of ZO1, suggesting a role in epithelial barrier disruption and disease severity.

bioRxiv · Dec 22, 2020Microbiology