Mitochondrial defects and metabolic vulnerabilities in Lynch syndrome-associated MSH2-deficient endometrial cancer
M. B. Bowen, B. D. Melendez, Q. Zhang, D. Moreno, L. Peralta, W. K. Chan, C. Jeter, L. Tan, M. A. Zal, P. L. Lorenzi, K. Dunner, R. K. Yang, R. R. Broaddus, J. Celestino, N. T. Gokul, , M. S. Yates
This study identifies mitochondrial dysfunction and metabolic reprogramming in MSH2-deficient endometrial cancer, revealing a novel pathway and potential therapeutic targets.
JCI Insight · Feb 18, 2025Peer-reviewedCancer Biology