L. Tan

Fiber optical parametric amplification of low-photon-flux microscopy signals

This paper demonstrates fiber optical parametric amplification to boost low-photon-flux microscopy signals, achieving higher sensitivity and bandwidth than conventional detectors.

Mitochondrial defects and metabolic vulnerabilities in Lynch syndrome-associated MSH2-deficient endometrial cancer

This study identifies mitochondrial dysfunction and metabolic reprogramming in MSH2-deficient endometrial cancer, revealing a novel pathway and potential therapeutic targets.

Coronavirus Nucleocapsid Protein Enhances the binding of p-PKCα to RACK1: Implications for Inhibition of Nucleocytoplasmic Trafficking and Suppression of the Innate Immune Response

This study identifies how the coronavirus N protein disrupts nucleocytoplasmic trafficking and suppresses the innate immune response by promoting RACK1-PKC interaction and NUP62 phosphorylation.

Colorectal ALOX15 as a host factor determinant of EPA and DHA effects on colorectal carcinogenesis

This study shows that ALOX15 expression modulates EPA and DHA effects on colorectal carcinogenesis by promoting resolvin generation, which suppresses pro-tumorigenic inflammation.

CDK4 or CDK6 upregulation induces DNA replication stress and genomic instability to cause EGFR targeted therapy resistance in lung cancer

This study shows that CDK4/6 upregulation causes DNA replication stress and genomic instability, leading to resistance to EGFR inhibitors in lung cancer, and suggests combining CDK4/6 and EGFR inhibitors as a treatment.

Aerobic exercise promotes PDAC vascular normalization through S1PR1 signaling in tumor endothelial cells

This study shows aerobic exercise improves PDAC vascular function and chemotherapy efficacy via S1PR1 signaling in tumor endothelial cells.

Tryptophan Metabolites And Their Predicted Microbial Sources In Fecal Samples From Healthy Individuals

The paper measures tryptophan metabolites in fecal samples from healthy individuals and links them to bacterial abundance and predicted microbial sources.

IL-1B-mediated inflammatory signaling drives ineffective erythropoiesis in early-stage myelodysplastic syndromes

This study shows that IL-1B-mediated inflammation drives ineffective erythropoiesis in early-stage MDS and that canakinumab can reduce transfusion dependence in patients with DNMT3A and TET2 mutations.

Artificially cultivated duckweed: a high-efficiency starch producer

This paper reports a method to produce starch efficiently from duckweed under specific conditions and identifies mechanisms behind its high starch accumulation.

Duckweed evolution: from land back to water

This study investigates the reverse evolution of duckweed from land back to water, showing gradual degeneration in root structure, stomatal function, and lignocellulose content, along with gene pathway changes.

Coronavirus endoribonuclease nsp15 induces host cellular protein synthesis shutoff

This study shows that coronavirus nsp15 inhibits host protein synthesis and targets host mRNA, with EndoU activity essential for these effects and virus replication.

Targeting DNA2 Overcomes Metabolic Reprogramming in Multiple Myeloma

This study identifies DNA2 as a key factor in mitochondrial metabolism that enables multiple myeloma cells to survive DNA damage, showing that targeting DNA2 overcomes metabolic reprogramming and enhances therapy effectiveness.

TERT accelerates BRAF mutant-induced thyroid cancer dedifferentiation and progression by regulating ribosome biogenesis

This study shows TERT promotes thyroid cancer dedifferentiation and progression by enhancing ribosome biogenesis, and inhibiting rRNA synthesis can reverse this process.

Disrupted trans-placental thyroid hormone transport in a human model for MCT8 deficiency

The paper investigates disrupted trans-placental thyroid hormone transport in a human model of MCT8 deficiency, showing impaired T4 transfer and altered fetal thyroid hormone levels.

Vitamin B2 enables peroxisome proliferator-activated receptor α regulation of fasting glucose availability

This study shows that vitamin B2 deficiency impairs PPAR regulation of fasting glucose, and PPAR agonists can rescue this defect.

Nitroimidazopyrazinones with oral activity against tuberculosis and Chagas disease in mouse models of infection

This paper evaluates nitroimidazopyrazinone derivatives for antitubercular and antiparasitic activity, showing selectivity against M. tuberculosis and efficacy against T. cruzi in mouse models.

Diving Behavior Reveals Humidity Sensing Ability of Water Deprived Planarians

This study shows that aquatic planarians can sense humidity and use this ability to find water during drought by diving behavior.

Mitochondrial structure and function adaptation in residual triple negative breast cancer cells surviving chemotherapy treatment

This study identifies how residual triple negative breast cancer cells adapt mitochondrial structure and function to survive chemotherapy, showing that DNA-damaging agents promote mitochondrial fusion and OXPHOS, which can be targeted with OPA1 inhibitors.

Heparan Sulfate-dependent RAGE oligomerization is indispensable for pathophysiological functions of RAGE

This study shows that heparan sulfate-dependent RAGE oligomerization is essential for RAGE signaling and demonstrates a monoclonal antibody that blocks this interaction.

Diet-derived metabolites and mucus link the gut microbiome to fever after cytotoxic cancer treatment

The paper links diet-derived metabolites and mucus to fever after cytotoxic cancer treatment by showing how Akkermansia muciniphila affects colonic mucus and inflammation.

Caspase-dependent cleavage of DDX21 suppresses host innate immunity

This study identifies DDX21 cleavage by caspase-3/6 during virus infection as a mechanism to suppress IFN-β signaling by disrupting the DDX1-DDX21-DHX36 complex.

High Throughput Virtual Screening and Validation of a SARS-CoV-2 Main Protease Non-Covalent Inhibitor

This paper identifies a novel non-covalent inhibitor of SARS-CoV-2 main protease through high throughput virtual screening, validated by biochemical assays, X-ray crystallography, and molecular dynamics simulations.

Inhibition of Anti-viral Stress Granule Formation by infectious bronchitis virus endoribonuclease nsp15 Ensures Efficient Virus Replication

This study shows that IBV uses nsp15 to inhibit stress granule formation, thereby evading antiviral responses and promoting viral replication.

Newcastle disease virus induced ferroptosis through p53-SLC7A11-GPX4 axis mediated nutrient deprivation in tumor cells

This study shows that Newcastle disease virus induces ferroptosis in tumor cells via the p53-SLC7A11-GPX4 pathway, leading to nutrient deprivation and cell death.

Targeted cancer therapy induces APOBEC fuelling the evolution of drug resistance

This study shows that targeted cancer therapy induces APOBEC-mediated mutagenesis, promoting drug resistance by increasing genetic diversity through mechanisms involving NF-κB activation and reduced DNA repair.

Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection

This study compares T cell responses in asymptomatic and symptomatic SARS-CoV-2感染者, finding that asymptomatic individuals have a robust and functional immune response with balanced cytokine production.

Medium-chain acyl-CoA dehydrogenase, a gatekeeper of mitochondrial function in glioblastoma multiforme

This study identifies MCAD as a critical enzyme for fatty acid metabolism in GBM, showing its essential role in preventing mitochondrial damage and apoptosis.

Evaluation of SARS-CoV-2 neutralizing antibodies using a vesicular stomatitis virus possessing SARS-CoV-2 spike protein

This study evaluates SARS-CoV-2 neutralizing antibodies using a pseudotyped virus assay and compares results with immunofluorescence assay findings.

A fetal wave of human type-3 γδ T cells with restricted TCR diversity persists into adulthood

The paper identifies a fetal wave of human type-3 γδ T cells with restricted TCR diversity that persists into adulthood using single-cell RNA-sequencing and TCR-sequencing.

Catalytic domain plasticity of MKK7 reveals structural mechanisms of allosteric activation and new targeting opportunities

This study presents MKK7 crystal structures and identifies new allosteric targets, revealing structural mechanisms of activation and potential drug candidates.