An SNP variant MT1-MMP with a defect in its collagenolytic activity confers the fibrotic phenotype of Dupuytren's Disease
Y. Itoh, M. Ng, A. Wiberg, K. Inoue, N. Hirata, K. B. Paiva, N. Ito, K. Dzobo, N. Sato, V. Gifford, Y. Fijita, M. Inada, D. Furniss
This study identifies an SNP variant in MMP14 that reduces collagenolytic activity, contributing to the fibrotic phenotype of Dupuytren's Disease.
bioRxiv · Jun 9, 2020Biochemistry