K. Inoue

SLC35G1: A highly chloride-sensitive transporter responsible for the basolateral membrane transport in intestinal citrate absorption

This study identifies SLC35G1 as a chloride-sensitive transporter responsible for basolateral citrate absorption in the intestine.

Element accumulation in the tracheal and bronchial cartilages of monkeys

The paper analyzes element accumulation in monkey tracheal and bronchial cartilages, finding higher calcium, phosphorus, and zinc levels in tracheal cartilage and age-related calcium increases.

Defense-related callose synthase PMR4 promotes root hair callose deposition and adaptation to phosphate deficiency in Arabidopsis thaliana

This study identifies PMR4 callose synthase as essential for root hair callose deposition under phosphate deficiency, improving Pi acquisition and plant growth.

mRNA vaccine induces protective immunity against the type III secretory virulence of Pseudomonas aeruginosa

This study develops an mRNA vaccine targeting Pseudomonas aeruginosa's type III secretion system, showing improved mouse survival and reduced lung bacterial load after challenge.

Biosynthesis of gibberellin-related compounds modulates far-red light responses in the liverwort Marchantia polymorpha

This study shows that GA-related compounds in liverworts modulate far-red light responses, revealing evolutionary conservation and functional divergence in GA biosynthesis.

Reprogramming Intrahepatic Cholangiocarcinoma Immune Microenvironment by Chemotherapy and CTLA-4 Blockade Enhances Anti-PD1 Therapy

This paper shows that combining chemotherapy with CTLA-4 blockade reprograms the immune microenvironment of intrahepatic cholangiocarcinoma, enhancing the effectiveness of anti-PD1 therapy.

Structural basis for ion selectivity in potassium-selective channelrhodopsins

The paper determines the cryo-EM structures of two K+-selective channelrhodopsins, revealing a unique mechanism for K+ selectivity distinct from canonical K+ channels.

Energy transfer in ubiquitous rhodopsin pumps with xanthophyll antennas

The paper detects energy transfer from hydroxylated carotenoids to rhodopsin proton pumps in marine and freshwater bacteria.

Bone marrow AdipoQ-lineage progenitors are a major cellular source of M-CSF that dominates bone marrow macrophage development, osteoclastogenesis and bone mass

The paper identifies bone marrow AdipoQ-lineage progenitors as a major source of M-CSF, showing their critical role in macrophage development, osteoclastogenesis, and bone mass regulation.

IFNA pathway drives the more aggressive phenotype of KRASG12D-mutant pancreatic ductal adenocarcinomas via IFNAR1/STAT3 activation

The paper shows that the IFNA pathway promotes aggressive KRASG12D-mutant pancreatic ductal adenocarcinomas through IFNAR1/STAT3 activation and identifies IFNAR1 inhibition as a potential therapeutic strategy.

Inflammasome targeting with an NLRP3 agonist therapy is feasible but ineffective in murine hepatocellular carcinoma models with liver damage

This study tests an NLRP3 agonist added to PD-1/VEGFR inhibitors in murine HCC models with liver damage, finding it feasible but ineffective in improving tumor outcomes.

Proton-transporting heliorhodopsins from marine giant viruses

This paper identifies a light-gated proton channel in a viral heliorhodopsin from Emiliania huxleyi virus 202, showing its potential role in host manipulation and optogenetic applications.

Saccharibacteria harness light energy using Type-1 rhodopsins that may rely on retinal sourced from microbial hosts

The paper identifies Saccharibacteria using Type-1 rhodopsins that pump protons and rely on retinal from microbial hosts, suggesting a symbiotic relationship for energy generation.

A stepwise route to domesticate rice by controlling seed shattering and panicle shape

This study identifies multiple genetic mutations required for rice domestication, showing that seed shattering loss alone is insufficient and that panicle shape plays a critical role in yield increase.

Structural basis for channel conduction in the pump-like channelrhodopsin ChRmine

The paper presents the cryo-EM structure of ChRmine, revealing unique architectural features and provides insights into its conduction mechanism and potential for optogenetic applications.

Characterization of heliorhodopsins detected via functional metagenomics in freshwater Actinobacteria, Chloroflexi and Archaea

This paper discovers and characterizes ten new heliorhodopsins from freshwater microbes using functional metagenomics, revealing their light absorption properties and potential roles in membrane lipid remodeling and oxidative stress.

Coordination between growth and stress responses by DELLA in the liverwort Marchantia polymorpha

This study shows that DELLA in the liverwort Marchantia polymorpha coordinates growth and stress responses, similar to vascular plants, and interacts with MpPIF to promote oxidative stress tolerance.

Wrinkle force microscopy: a new machine learning based approach to predict cell mechanics from images

This paper introduces a machine learning method to predict cellular forces from microscope images by training on wrinkle patterns and traction force data.

Heliorhodopsin evolution is driven by photosensory promiscuity in monoderms

This study identifies heliorhodopsins (HeRs) as a novel type-3 rhodopsin family restricted to monoderms, likely functioning as light-dependent switches for stress mitigation and metabolic regulation.

Crystal structure of schizorhodopsin reveals mechanism of inward proton pumping

The paper reports the crystal structure of schizorhodopsin, revealing its mechanism of inward proton pumping and differences from xenorhodopsins.

An SNP variant MT1-MMP with a defect in its collagenolytic activity confers the fibrotic phenotype of Dupuytren's Disease

This study identifies an SNP variant in MMP14 that reduces collagenolytic activity, contributing to the fibrotic phenotype of Dupuytren's Disease.

Exploration of natural red-shifted rhodopsins using a machine learning-based Bayesian experimental design

The paper uses a machine learning model to identify red-shifted rhodopsins, finding 80% of selected candidates show red-shift gains, with some having desirable ion-transporting properties.

Chloroplast chaperonin-mediated targeting of a thylakoid membrane protein

The paper shows chloroplast chaperonin Cpn60 captures and releases Plsp1 for thylakoid membrane integration, while cpSecA1 recognizes free Plsp1 for insertion.

Lab-on-a-graphene-FET detection of key molecular events underpinning influenza virus infection and effect of antiviral drugs

This study uses graphene-FETs to detect molecular events during influenza infection and monitor antiviral drug effects in real-time.

Multiplexed 129Xe HyperCEST MRI detection of genetically-reconstituted bacterial protein nanoparticles in human cancer cells.

The paper genetically reconstitutes bacterial protein nanoparticles in human cancer cells and demonstrates their use as contrast agents for HyperCEST MRI.

Lipid Chaperoning of a Thylakoid Protease Whose Stability is Modified by the Protonmotive Force

The paper investigates how lipid interactions and disulfide bonds affect the stability and activity of Plsp1, a thylakoid membrane protease, under varying pH conditions.

Origination of the circadian clock system in stem cells regulates cell differentiation in Arabidopsis thaliana.

The paper shows that the circadian clock in Arabidopsis stem cells regulates cell differentiation through BES1-mediated repression of LHY.

The sunlit microoxic niche of the archaeal eukaryotic ancestor comes to light

The paper uses phylogenetic analyses and metabolic reconstructions to infer the lifestyle and metabolic environment of the closest archaeal relatives of eukaryotes, revealing microoxic lifestyles and novel metabolic pathways.

Heliorhodopsins are absent in diderm (Gram-negative) bacteria: Some thoughts and possible implications for activity

The paper examines the presence of heliorhodopsins in diderm bacteria using metagenomic data and finds they are absent, suggesting a possible role in light-driven transport of amphiphilic molecules.