Antigen non-specific CD8+ T cells accelerate cognitive decline in aged mice following respiratory coronavirus infection
K. L. Reagin, R.-L. Lee, L. Cocciolone, K. E. Funk
This study shows that aged mice infected with coronavirus have increased brain CD8+ T cells that cause cognitive decline through IFN-gamma secretion.
bioRxiv · Jan 2, 2024 · PreprintImmunology