Targeting Epsins by nanotherapy regulates lipid metabolism and promotes ABCG1-mediated cholesterol efflux to fortify atheroma regression
K. Cui, X. Gao, B. Wang, H. Wu, Y. Dong, Y. Xiao, X. Jiang, M. V. Malovichko, K. Li, Q. Peng, Y. W. Lu, B. Zhu, R. Zheng, S. Wong, D. B. Cowan, , H. Chen
This study shows that targeting Epsins in macrophages with nanotherapy reduces lipid uptake and increases cholesterol efflux, promoting atheroma regression.
bioRxiv · Aug 9, 2022 · PreprintCell Biology