Author

D. B. Cowan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 6

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 6 Research Focus:differential expression· 5 Organism:mouse· 5 Approach:experimental assay· 3 Assay:scRNA-seq· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2

Frequent Co-Authors

H. Chen· 5 shared S. Wong· 5 shared B. Wang· 4 shared B. Zhu· 4 shared H. Wu· 4 shared K. Cui· 4 shared S. Bhattacharjee· 3 shared S. Eisa-Beygi· 3 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersCell Biology

H. Chen

Mutual co-authors in cluster

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6 papers

Recent·Most cited

Interplay Between FoxM1 and Dab2 Promotes Endothelial Cell Responses in Diabetic Wound Healing

S. Bhattacharjee, J. Gao, Y. W. Lu, S. Eisa-Beygi, H. Wu, K. S. Li, A. E. Birsner, S. Wong, Y. Song, J. Y.-J. Shyy, D. B. Cowan, W. Wei, M. Aikawa, J. Shi, H. Chen

This study identifies Dab2 and FoxM1 as key regulators of endothelial dysfunction in diabetes, showing that restoring Dab2 improves angiogenesis and wound healing.

bioRxiv · Feb 7, 2024 · PreprintCell Biology

Epsins oversee smooth muscle cell reprogramming by influencing master regulators KLF4 and OCT4.

B. Wang, K. Cui, B. Zhu, Y. Dong, D. Wang, B. Singh, H. Wu, K. Li, S. Eisa-Beygi, Y. Sun, S. Wong, D. B. Cowan, Y. Chen, M. Du, H. Chen

This study shows Epsins regulate smooth muscle cell reprogramming by modulating OCT4 and KLF4, with implications for coronary artery disease.

bioRxiv · Jan 8, 2024 · PreprintCell Biology

Targeting endothelial FOXO1 protects diabetic β-cells and improves wound healing

H. Wu, K. Cui, B. Zhu, Y. W. Lu, L. Sun, Q. Ma, A. Jian, D. O. Hurtado, X. Gao, Y. Li, S. Bhattacharjee, H. Fu, A. E. Birsner, M. Malovichko, M. Li, , H. Chen

This study shows that targeting endothelial FOXO1 reduces IGF2 levels, improves β-cell function, and enhances wound healing in diabetes.

bioRxiv · Dec 4, 2023 · PreprintCell Biology

Targeting Epsins by nanotherapy regulates lipid metabolism and promotes ABCG1-mediated cholesterol efflux to fortify atheroma regression

K. Cui, X. Gao, B. Wang, H. Wu, Y. Dong, Y. Xiao, X. Jiang, M. V. Malovichko, K. Li, Q. Peng, Y. W. Lu, B. Zhu, R. Zheng, S. Wong, D. B. Cowan, , H. Chen

This study shows that targeting Epsins in macrophages with nanotherapy reduces lipid uptake and increases cholesterol efflux, promoting atheroma regression.

bioRxiv · Aug 9, 2022 · PreprintCell Biology

Targeting Epsins to Inhibit FGF Signaling while Potentiating TGF-beta Signaling Constrains Endothelial-to-Mesenchymal Transition in Atherosclerosis

Y. Dong, B. Wang, M. Du, B. Zhu, K. Cui, S.-L. Chan, D. B. Cowan, S. Bhattacharjee, S. Wong, J. Bischoff, M. F. Linton, H. Chen

This study identifies epsins as promoters of endothelial-to-mesenchymal transition in atherosclerosis and shows that a therapeutic peptide targeting epsin-FGFR1 interaction reduces EndoMT and atherosclerosis progression.

bioRxiv · Aug 9, 2022 · PreprintCell Biology

Transit and integration of extracellular mitochondria in human heart cells

D. B. Cowan, R. Yao, J. K. Thedsanamoorthy, D. Zurakowski, P. J. del Nido, J. D. McCully

This study shows that exogenous mitochondria can be internalized and integrated into human cardiac cells, improving energy production and reducing cell death after ischemic injury.

bioRxiv · Jun 28, 2017Cell Biology