IRAK1 is a critical mediator of low molecular weight hyaluronic acid-induced stemness in high-grade serous ovarian cancer
D. Standing, P. Dandawate, S. Gunewardena, O. Covarrubias-Zambrano, K. F. Roby, D. Khabele, A. Jewell, O. Tawfik, S. H. Bossmann, A. K. Godwin, S. J. Weir, R. A. Jensen, S. Anant
This study identifies IRAK1 as a key mediator of LMW HA-induced stemness in EOC, showing its role in chemoresistance and demonstrating TCS2210 as a potential inhibitor.
bioRxiv · Sep 25, 2023 · PreprintCancer Biology