MicrobiologybioRxivPreprint
Orientia tsutsugamushi Ank5 directs ubiquitination and proteasomal degradation of NLRC5 to inhibit major histocompatibility complex class I expression
H. Adcox, J. R. Hunt, K. G. Rodino…·J. A. Carlyon
This study identifies Ank5 as a bacterial effector that degrades NLRC5 to inhibit MHC class I expression, revealing a mechanism for immune evasion by Orientia tsutsugamushi.
DOI 10.1101/2023.12.04.569938