K. Gomez

A single shot of a hybrid hAdV5-based anti-COVID-19 vaccine induces a long-lasting immune response and broad coverage against VOC

This paper describes a single-dose hybrid hAdV5-based vaccine that induces long-lasting immunity and broad neutralization against SARS-CoV-2 variants.

Lipocalin 2 promotes inflammatory breast cancer tumorigenesis and skin invasion

This study shows that lipocalin 2 promotes inflammatory breast cancer aggressiveness and skin invasion by enhancing proliferation, migration, and metastasis.

Random peptides rich in small and disorder-promoting amino acids are less likely to be harmful

The paper investigates which random peptides are less harmful by analyzing their amino acid composition and fitness effects in E. coli.

Mutation bias can shape adaptation in large asexual populations experiencing clonal interference

The paper shows mutation-biased adaptation can occur in asexual populations despite clonal interference, depending on mutation rate and selection coefficient differences.

Directional selection rather than functional constraints can shape the G matrix in rapidly adapting asexuals

The paper shows that directional selection, not functional constraints, shapes the G matrix in asexual populations through linkage disequilibrium rather than pleiotropy.

Predicting clone genotypes from tumor bulk sequencing of multiple samples

The paper evaluates nine computational methods for inferring clone genotypes from bulk tumor sequencing data, finding that most perform poorly on datasets with mixed clonal lineages.

Computational enhancement of single-cell sequences for inferring tumor evolution

This paper introduces BEAM, a Bayesian method for improving single-cell tumor sequencing data by leveraging evolutionary information, showing it outperforms existing methods in imputing missing bases and correcting false positives/negatives.