Rapid tolerance to morphine in the myenteric neurons of the small intestine is independent of β-arrestin-2 and mediated by PKC
K. H. Muchhala, J. C. Jacob, I. Alam, S. Hasan, A. Khan, M. Kang, W. L. Dewey, H. I. Akbarali
This study shows that morphine tolerance in the small intestine develops rapidly and is independent of β-arrestin-2 but mediated by PKC, unlike peripheral antinociceptive tolerance.
bioRxiv · Jul 17, 2020 · PreprintPharmacology & Toxicology