S. Hasan

Dietary Pyruvate Targets Cytosolic Phospholipase A2 to Mitigate Inflammation and Obesity in Mice

This study identifies pyruvate as an inhibitor of cPLA2 that reduces obesity and inflammation in mice by targeting this enzyme, suggesting its potential as a therapeutic agent.

Novel protein interaction network of human calcitonin receptor-like receptor revealed by label-free quantitative proteomics

The paper identifies 46 novel proteins interacting with CLR in primary human dermal lymphatic endothelial cells using immunoprecipitation and mass spectrometry, confirmed by proximity ligation assay.

Novel Peptide Inhibitor of Human Tumor Necrosis Factor-α has Antiarthritic Activity

The paper designs a peptide inhibitor of TNF-α that reduces inflammation and joint damage in arthritis models.

Challenges in modelling the sediment retention ecosystem service for an ecosystem account, with examples from the Mitchell catchment

The paper evaluates sediment retention ecosystem service models in the Mitchell catchment, finding large discrepancies between uncalibrated models and empirical data, highlighting the need for local calibration.

Ecosystem services in connected catchment to coast ecosystems: monitoring to detect emerging trends

The paper tests ecological indicators in a catchment-to-coast system to determine their response times to environmental change, finding they require over 10 years to detect trends.

Injectable Progranulin-derivative Atsttrin loaded Protein Engineered Gels for Post Traumatic Osteoarthritis

This paper develops a protein-based gel that delivers Atsttrin to prevent post-traumatic osteoarthritis in a rabbit model.

Rapid tolerance to morphine in the myenteric neurons of the small intestine is independent of β-arrestin-2 and mediated by PKC

This study shows that morphine tolerance in the small intestine develops rapidly and is independent of β-arrestin-2 but mediated by PKC, unlike peripheral antinociceptive tolerance.

An in vitro assessment of anti-SARS-CoV-2 activity of oral preparations of iodine complexes (RENESSANS)

This study assesses the in vitro anti-SARS-CoV-2 activity of iodine complex oral formulations, finding that higher concentrations show significant inhibition of viral replication and cytopathic effects.

The NAD+-dependent deacetylase Sir2 enables evolution of new traits by regulating distinct gene sets in two yeast species, Saccharomyces cerevisiae and Kluyveromyces lactis

This study shows that sirtuin deacetylases regulate distinct gene sets in two yeast species, enabling adaptive responses to low NAD+ stress through species-specific transcriptional rewiring.