Author

K. Haldar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Microbiology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

A. Amirthanayagam· 1 shared A. Piskorz· 1 shared B. Basu· 1 shared B. Davies· 1 shared C. Caldas· 1 shared C. Sauer· 1 shared C. Swanton· 1 shared D. Sanders· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

A. Amirthanayagam

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3 papers

Recent·Most cited

Simultaneous adjunctive treatment of malaria and its co-evolved genetic disorder sickle cell anaemia

I. Safeukui, R. E. Ware, M. Narla, K. Haldar

This paper shows hydroxyurea reduces clinical malaria in sickle cell anemia patients and has intrinsic antimalarial activity.

bioRxiv · Sep 1, 2022 · PreprintMicrobiology

Somatic chromosomal number alterations affecting driver genes inform in-vitro and clinical drug response in high-grade serous ovarian cancer

F. Correia Martins, D.-L. Couturier, I. Santiago, C. Sauer, M. Vias, M. Angelova, D. Sanders, A. Piskorz, J. Hall, K. Hosking, A. Amirthanayagam, S. Cosulich, L. Carnevalli, B. Davies, T. B. K. Watkins, , J. D. Brenton

This study shows that somatic copy number alterations in driver genes correlate with drug response in HGSOC spheroid models and clinical settings.

bioRxiv · Oct 4, 2020 · PreprintCancer Biology

Algorithmic Assessment of Missense Mutation Severity in the Von-Hippel Lindau Protein

F. Fields, N. Suresh, M. Hiller, S. Freed, K. Haldar, S. Lee

The paper develops a multiparametric scoring algorithm to assess the severity of missense mutations in the VHL protein using 285 ClinVar mutations, linking higher scores to pathogenicity.

bioRxiv · May 20, 2020Pathology