Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
8 papers
Recent·Most cited
L. Morrill Gavarro, D.-L. Couturier, F. Markowetz
This paper introduces a Dirichlet-multinomial mixed model to analyze differential abundance of mutational signatures across clonal and subclonal mutations in cancer, finding significant differences in mutational processes between these groups.
bioRxiv · Mar 7, 2024Cancer Biology
M.-E. Oraiopoulou, D.-L. Couturier, E. V. Bunce, I. Cannell, M. Golinska, G. J. Hannon, V. Sakkalis, S. E. Bohndiek
This study develops a framework to monitor and analyze the dynamic formation and dissolution of pseudo-vascular networks in vitro using time-resolved microscopy and image analysis, showing melanoma cells form the most stable networks and respond to specific drug treatments.
bioRxiv · Nov 2, 2023 · PreprintCancer Biology
Y. Boulaguiem, J. Quartier, M. Lapteva, Y. N. Kalia, M.-P. Victoria-Feser, S. Guerrier, D.-L. Couturier
The paper proposes a finite sample correction for the TOST procedure to improve power in equivalence testing, particularly for highly variable data.
bioRxiv · Mar 11, 2023Pharmacology & Toxicology
C. M. Sauer, J. A. Hall, D.-L. Couturier, T. Bradley, A. M. Piskorz, J. Griffiths, A. Sawle, M. D. Eldridge, P. Smith, K. Hosking, M. A. Reinius, L. Morrill Gavarro, A.-M. Mes-Masson, D. Ennis, D. Millan, , J. D. Brenton
This study identifies centrosome amplification as a common and heterogeneous feature in HGSOC, linked to CIN and treatment resistance.
bioRxiv · Sep 13, 2022Cancer Biology
M. Vias, L. Morrill Gavarro, C. M. Sauer, D. Sanders, A. M. Piskorz, D.-L. Couturier, S. Ballereau, B. Hernando, J. Hall, F. Correia-Martins, F. Markowetz, G. Macintyre, J. D. Brenton
This study develops HGSOC patient-derived organoids to model chromosomal instability and its mutational processes, showing they represent different causes of instability and can be used for drug sensitivity testing.
bioRxiv · Sep 1, 2022Cancer Biology
C. M. Sauer, K. Heider, J. Belic, S. E. Boyle, J. A. Hall, D.-L. Couturier, A. An, A. Vijayaraghavan, M. A. Reinius, K. Hosking, M. Vias, N. Rosenfeld, J. D. Brenton
This study develops a method to monitor ctDNA in PDX mice using dried blood spots, enabling longitudinal tracking of disease burden and treatment response.
bioRxiv · Jan 15, 2022Cancer Biology
F. Correia Martins, D.-L. Couturier, I. Santiago, C. Sauer, M. Vias, M. Angelova, D. Sanders, A. Piskorz, J. Hall, K. Hosking, A. Amirthanayagam, S. Cosulich, L. Carnevalli, B. Davies, T. B. K. Watkins, , J. D. Brenton
This study shows that somatic copy number alterations in driver genes correlate with drug response in HGSOC spheroid models and clinical settings.
bioRxiv · Oct 4, 2020 · PreprintCancer Biology
A. Jimenez-Sanchez, P. Cybulska, K. Lavigne, T. Walther, I. Nikolovski, Y. Mazaheri, B. Weigelt, D. S. Chi, K. J. Park, T. Hollmann, D.-L. Couturier, A. Vargas, J. D. Brenton, E. Sala, A. Snyder, M. L. Miller
This study analyzes tumor-immune heterogeneity in ovarian cancer before and after chemotherapy, finding that chemotherapy increases cytotoxic immune activation in site-matched samples.
bioRxiv · Oct 17, 2018Cancer Biology