J. Hall

miRNA-29-CLIP uncovers new targets and functions to improve skin repair

This study identifies miRNA-29 targets and functions in skin repair using miRNA-CLIP and ASO, revealing roles in protein folding, RNA processing, and cell adhesion.

Identification of a novel papillomavirus from a New Zealand fur seal (Arctocephalus forsteri) with oral papilloma-like lesions

The paper identifies a novel papillomavirus, AfPV1, in New Zealand fur seals with oral papilloma-like lesions and detects a novel gammaherpesvirus, AfGHV1, in another individual.

Oligo-PROTAC strategy for cell-selective and targeted degradation of activated STAT3

This paper develops a PROTAC-based strategy to selectively degrade activated STAT3 in specific cell types, showing efficacy in reducing STAT3 levels and tumor growth in lymphoma models.

Low-troposphere microbial communities differ between dry-air and rainfall but do not show strong seasonal patterns in Metro Atlanta, Southeast USA

The paper compares microbial communities in dry air and rainfall in Metro Atlanta, finding dry air has more human pathogens and allergens, but no strong seasonal patterns.

MerTK mediates the immunologically silent uptake of alpha-synuclein fibrils by human microglia

This study shows MerTK mediates microglial uptake of alpha-synuclein fibrils without triggering inflammation and links MERTK variants to Parkinson's disease.

Gammaretroviruses, novel viruses and pathogenic bacteria in Australian bats with neurological signs, pneumonia and skin lesions

This study identifies pathogens in Australian bats with neurological signs, pneumonia, and skin lesions using metatranscriptomic sequencing and traditional diagnostics.

High-grade serous ovarian carcinoma organoids as models of chromosomal instability

This study develops HGSOC patient-derived organoids to model chromosomal instability and its mutational processes, showing they represent different causes of instability and can be used for drug sensitivity testing.

Drug-gene interaction screens coupled to tumour data analyses identify the most clinically-relevant cancer vulnerabilities driving sensitivity to PARP inhibition

The paper identifies 110 genes linked to PARP inhibitor sensitivity through CRISPR screens and tumor data analysis, highlighting XRCC3 as a potential biomarker for prostate cancer.

Exploring the in-situ evolution of Nitrofurantoin resistance in clinically derived Uropathogenic Escherichia coli isolates.

This study investigates the in situ evolution of Nitrofurantoin resistance in uropathogenic E. coli isolates from two UTI patients, finding no fitness advantage for resistant strains but a selective advantage at sub-MIC concentrations.

Experimental infection of Mexican free-tailed bats (Tadarida brasiliensis) with SARS-CoV-2.

This study infects Mexican free-tailed bats with SARS-CoV-2 and finds they can become infected but do not show disease symptoms or transmit the virus.

Plasmid manipulation of bacterial behaviour through translational regulatory crosstalk

This paper identifies RsmQ as a plasmid translational regulator that globally controls bacterial behavior by altering the proteome, leading to a switch from motile to sessile lifestyle.

A highly sensitive protein-RNA cross-linking mass spectrometry workflow with enhanced structural modelling potential

This paper improves a CLIR-MS workflow for protein-RNA cross-linking, increasing detected products and enabling structural restraint analysis.

Evasion of Toll-like Receptor Recognition by Escherichia coli is mediated via Population Level Regulation of Flagellin Production

This study shows that uropathogenic E. coli evades TLR5 recognition by regulating flagellin production at the population level, not through antigenic variation.

Re-investigating the coughing rat model of pertussis to understand Bordetella pertussis pathogenesis

This study uses a rat model to compare disease manifestations between two genetically distinct Bordetella pertussis strains, finding that D420 induces more severe coughing and immune responses than Tohama 1.

Integrating deep learning and unbiased automated high-content screening to identify complex disease signatures in human fibroblasts

This study develops a platform combining deep learning and high-content imaging to identify disease-specific phenotypes in Parkinson's fibroblasts, achieving high accuracy in distinguishing disease subtypes.

The proficiency of the original host species determines community-level plasmid dynamics

The study shows that the proficiency of host species in maintaining plasmids affects plasmid abundance and dissemination in bacterial communities.

Somatic chromosomal number alterations affecting driver genes inform in-vitro and clinical drug response in high-grade serous ovarian cancer

This study shows that somatic copy number alterations in driver genes correlate with drug response in HGSOC spheroid models and clinical settings.

Positive selection inhibits plasmid coexistence in bacterial genomes

The paper shows that positive selection inhibits plasmid coexistence in bacterial genomes by retaining only the more beneficial plasmid, while compensatory evolution allows stable coinfection without positive selection.

Meta-transcriptomic analysis of virus diversity in urban wild birds with paretic disease

The paper identifies novel viruses in urban wild birds with paresis using meta-transcriptomic analysis and finds potential viral causes of neurological and muscular diseases.

Meta-transcriptomic discovery of a divergent circovirus and a chaphamaparvovirus in captive reptiles with proliferative respiratory syndrome

The paper identifies two novel viruses in captive bearded dragons with respiratory disease using meta-transcriptomic sequencing.

Detection of Chemotherapy-Resistant Pancreatic Cancer Using a Glycan Biomarker

This paper identifies sTRA as a glycan biomarker for chemotherapy-resistant pancreatic cancer, showing its presence correlates with poor treatment response in multiple systems.

NLRP3 controls ATM activation in response to DNA damage.

This study shows NLRP3 interacts with ATM to regulate DNA damage response, and its loss reduces ATM activation and confers resistance to genomic stress in NSCLC.

Activation and self-inactivation mechanisms of the cyclic oligoadenylate-dependent CRISPR ribonuclease Csm6

This study investigates how EiCsm6 degrades its activator cA6 and uses structural and functional analyses to reveal activation and self-inactivation mechanisms of the CRISPR ribonuclease.

The cation diffusion facilitator protein MamM's cytoplasmic domain exhibits metal-type dependent binding modes and discriminates against Mn2+

This study investigates how the cytoplasmic domain of the CDF protein MamM binds different metals, showing it discriminates against Mn2+ and supports a role for CTDs in metal selectivity.

Detection of ctDNA from dried blood spots after DNA size selection

This paper develops a protocol to detect ctDNA from dried blood spots using low-depth WGS and fragment size selection, showing its feasibility in human and mouse models.

Rapid and iterative genome editing in the zoonotic malaria parasite Plasmodium knowlesi: New tools for P. vivax research

This study develops CRISPR-Cas9 genome editing in Plasmodium knowlesi to generate a transgenic line expressing P. vivax Duffy binding protein, showing its role in host cell tropism and vaccine potential.

Smc5/6-antagonism by HBx is an evolutionary-conserved function of hepatitis B virus infection in mammals

This study shows HBx from diverse hepadnaviruses inactivates Smc5/6 in mammals, suggesting this is an evolutionary-conserved antiviral mechanism.

Type III CRISPR-Cas systems generate cyclic oligoadenylate second messengers to activate Csm6 RNases