Molecular Organization of the Early Stages of Nucleosome Phase Separation Visualized by Cryo-Electron Tomography
M. Zhang, C. D. Diaz-Celis, B. Onoa, C. Canari-Chumpitaz, K. I. Requejo, J. Liu, M. Vien, E. Nogales, G. Ren, C. Bustamante
This study uses cryo-electron tomography and deep learning to visualize the molecular organization of nucleosome phase separation stages, revealing a two-step process and the role of histone H1 in condensate transformation.
bioRxiv · Sep 1, 2021Biophysics